Fig. 1

The levels of urea concentration, osmolality in urine and flow chart of network building. From day 1 to 3: normal diet with free access to water. Day 4–7: 40 or 10 % protein in diet in the high-protein diet group or low-protein diet, respectively. Day 8–12: 40 % protein in diet with 3.5 μg/kg/12 h of dDAVP injection in the HPD group and 10 % protein in diet with 10 ml/12 h water injection in the LPD group; a Urinary urea concentration. b Urinary osmolality. n = 6; Mean ± SEM.; *P < 0.05, **P < 0.01 and ***P < 0.001; NS stands for no significant. c Process of the combination of the two networks. d The intersection sub-network generated by the results of microarray and proteomics using Advanced Network Merge plugin. Pink nodes represent the seed molecules. Blue nodes stand for the interacting proteins generated by Bisogenet, based on the protein well-known interaction databases; e 106 nodes contained in the microarray and proteomics were derived from the intersection sub-network and considered as significant mRNAs/proteins