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Table 2 mRNA expression of different genes involved in de novo lipogenesis in human visceral adipose tissue

From: Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue

 

Non-obese

subjects

(N = 15)

MO-low-IR subjects

(N = 15)

MO-high-IR subjects

(N = 15)

SIRT3

0.029 ± 0.014

0.021 ± 0.015

0.009 ± 0.006a*

PDHB

0.460 ± 0.170

0.244 ± 0.066a

0.248 ± 0.081a

ACC1

1.87 ± 0.43

1.15 ± 0.52a

0.91 ± 0.59a

ACSS2

1.14 ± 0.29

0.78 ± 0.42a

0.80 ± 0.39a

ACLY

1.01 ± 0.79

0.42 ± 0.08a

0.31 ± 0.06a

PPARγ

1.12 ± 0.65

2.72 ± 1.89a

2.51 ± 0.87a

SREBP-1c

0.271 ± 0.172

0.131 ± 0.072a

0.116 ± 0.067a

FASN

0.285 ± 0.088

0.148 ± 0.040a

0.124 ± 0.020a

  1. MO-low-IR morbidly obese subjects with low insulin resistance, MO-high-IR morbidly obese subjects with high insulin resistance
  2. aP < 0.05 significant differences with respect to the non-obese group
  3. * P < 0.05 significant differences between morbidly obese patients with low and high insulin resistance. All significant differences are adjusted for sex