Table 3 Multivariate cox regression analysis for OS of 134 patients with ESCC

HSF-1 expression in tumor cells (n = 134)

 Gender (male/female)

0.352 (0.177–0.700)

0.003*

0.401 (0.203–0.792)

0.009*

 Age (≤61/>61)

0.838 (0.546–1.286)

0.419

0.956 (0.607–1.506)

0.846

 Degree of differentiation (1/2/3)

1.195 (0.902–1.585)

0.215

1.199 (0.904–1.592)

0.208

 Tumor (T) status (1–2/3–4)

0.879 (0.449–1.720)

0.706

0.880 (0.447–1.732)

0.712

 Nodal (N) status (0/1)

2.977 (1.464–6.055)

0.003*

2.823 (1.376–5.791)

0.005*

 Metastasis (M) status (0/1)

1.350 (0.448–4.066)

0.594

1.392 (0.464–4.179)

0.555

 Clinical status (I II/III IV)

0.805 (0.520–1.247)

0.330

0.845 (0.541–1.322)

0.461

 HSF1 in tumor cell (low/high)

1.465 (0.916–2.341)

0.111

1.491 (0.928–2.396)

0.099

HSF1 expression in stromal cells (n = 134)

 Gender (male/female)

0.351 (0.177–0.696)

0.003*

0.411 (0.208–0.810)

0.010*

 Age (≤61/>61)

0.788 (0.511–1.215)

0.281

0.887 (0.562–1.399)

0.605

 Degree of differentiation (1/2/3)

1.143 (0.862–1.514)

0.354

1.157 (0.871–1.536)

0.314

 Tumor (T) status (1–2/3–4)

0.724 (0.363–1.441)

0.358

0.736 (0.368–1.472)

0.386

 Nodal (N) status (0/1)

2.490 (1.201–5.162)

0.014*

2.330 (1.104–4.918)

0.026*

 Metastasis (M) status (0/1)

1.032 (0.334–3.190)

0.956

1.108 (0.364–3.372)

0.856

 Clinical status (I II/III IV)

0.904 (0.577–1.414)

0.658

0.959 (0.604–1.523)

0.859

 HSF1 in stromal cell (low/high)

2.039 (1.243–3.345)

0.005*

2.000 (1.208–3.311)

0.007*

HSF1 expression in N0 (n = 65)

 Gender (male/female)

0.151 (0.039–0.586)

0.006*

0.199 (0.058–0.680)

0.010*

 Degree of differentiation (1/2/3)

1.666 (0.993–2.797)

0.053

1.691 (1.028–2.782)

0.039*

 HSF1 in tumor cell (low/high)

0.493 (0.126–1.931)

0.310

0.452 (0.110–1.867)

0.273

 HSF1 in stromal cell (low/high)

2.935 (0.634–13.591)

0.168

3.115 (0.712–13.624)

0.131

HSF1 expression in N1 (n = 69)

 HSF1 in tumor cell (low/high)

0.657 (0.235–1.833)

0.422

0.809 (0.292–2.245)

0.684

 HSF1 in stromal cell (low/high)

3.038 (1.055–8.753)

0.040*

2.617 (0.893–7.665)

0.079