Table 3 Liver expression of genes related to glucose metabolism
Protein | Gene | Hz vs. WT (fold change) | p value | Hz + IGF vs. Hz (fold change) | p value |
|---|---|---|---|---|---|
Fructosebisphosphatase 1 | (Fbp1) | 1.40 | 0.02 | −1.49 | 0.01 |
Fructosebisphosphatase 2 | (Fbp2) | 1.64 | 0.017 | 1.06 | 0.42 |
Glucose-6-phosphatase, catalytic | (G6pc) | −1.92 | 0.001 | −1.71 | 0.0059 |
Glucose 6 phosphatase, catalytic, 3 | (G6pc3) | −1.01 | 0.56 | 1.31 | 0.017 |
Phosphoenolpyruvatecarboxykinase 1, cytosolic | (Pck1) | −2.42 | 0.001 | 1.35 | 0.08 |
Phosphoenolpyruvatecarboxykinase 2 (mitochondrial) | (Pck2) | −1.14 | 0.45 | 1.10 | 0.40 |
Pyruvate carboxylase | (Pcx) | −1.01 | 0.18 | 1.05 | 0.09 |
Pyruvate dehydrogenase kinase, isoenzyme 1 | (Pdk1) | −1.46 | 0.0035 | 1.23 | 0.19 |
Pyruvate dehydrogenase kinase, isoenzyme 2 | (Pdk2) | −1.17 | 0.03 | 1.33 | 0.035 |
Pyruvate dehydrogenase kinase, isoenzyme 3 | (Pdk3) | 1.23 | 0.42 | −1.01 | 0.94 |
Pyruvate dehydrogenase kinase, isoenzyme 4 | (Pdk4) | −1.83 | 0.03 | −1.01 | 0.85 |
Pyruvate dehyrogenase phosphatase catalytic subunit 2 | (Pdp2) | −1.08 | 0.09 | 1.21 | 0.04 |
ATP citratelyase | (Acly) | −1.67 | 0.0007 | 1.60 | 0.006 |
Aconitase 1 | (Aco1) | −1.30 | 0.38 | 1.17 | 0.23 |
Aconitase 2, mitochondrial | (Aco2) | −1.18 | 0.013 | 1.16 | 0.85 |
Dihydrolipoamide S-acetyltransferase | (Dlat) | 1.03 | 0.13 | −1.15 | 0.19 |
Dihydrolipoamidedehydrogenase | (Dld) | −1.02 | 0.03 | 1.11 | 0.73 |
Dihydrolipoamide S-succinyltransferase | (Dlst) | 1.14 | 0.40 | 1.41 | 0.01 |
Isocitratedehydrogenase 1 (NADP+), soluble | (Idh1) | 1.07 | 0.04 | −1.38 | 0.07 |
Isocitratedehydrogenase 2 (NADP+), mitochondrial | (Idh2) | −1.10 | 0.45 | 1.01 | 0.25 |
Isocitratedehydrogenase 3 (NAD+) alpha | (Idh3a) | −1.21 | 0.09 | 1.06 | 0.01 |