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Table 3 Multivariate analysis of prognostic factors

From: Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedback loops signaling

Variable

Forward stepwise

Backward stepwise

 

HRa(95% CIb)

p

HR (95% CI)

p

Location of tumor

 

0.085

 

0.001*

 Head

-

 

1

 

 Body and tail

-

 

2.452 (1.414-4.253)

 

Differentiation

 

0.001*

 

<0.001*

 Well

1

 

1

 

 Moderate

2.368 (1.120-5.007)

0.024*

2.163 (0.994-4.706)

0.052

 Poor

6.603 (2.515-17.338)

<0.001*

7.076 (2.655-18.857)

<0.001*

TNM staging

 

0.175

 

0.014*

 IA + IB

-

 

1

 

 IIA

-

0.929

3.395 (1.414-8.148)

0.006*

 IIB

-

0.922

3.551 (1.523-8.277)

0.003*

 III + IV

-

0.077

4.218 (1.652-10.768)

0.003*

Serum CA19-9 (kU/L)

 

0.021*

 

0.008*

 ≤ 39

1

 

1

 

 > 39

1.914 (1.105-3.318)

 

2.817 (1.313-6.043)

 

Serum CA50 (kU/L)

 

0.535

 

0.085

 ≤ 25

-

 

1

 

 > 25

-

 

0.552 (0.280-1.086)

 

Serum CEA (μg/L)

 

0.265

 

0.089

 ≤ 4.3

-

 

1

 

 > 4.3

-

 

1.554 (0.934-2.584)

 

MUC4 (2-ΔCt)

 

0.001*

 

0.010*

 Low (<0.056)

1

 

1

 

 High (≥0.056)

2.281 (1.415-3.677)

 

1.976 (1.174-3.326)

 

MUC4/Y (2-ΔCt)

 

0.067

 

0.243

 Low (<0.0044)

-

 

-

 

 High (≥0.0044)

-

 

-

 
  1. aHR, hazard ratio; bCI, confidence interval; * p <0.05.