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Table 1 Clinicopathological factors and the expression of MUC4/Y in 108 patients with PDAC

From: Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedback loops signaling

Category

N(%)

MUC4/Y

  

Mean

Median(range)

PValue

Age(y)

    

<60

47 (43.52)

0.0076

0.0010(0.0000-0.0829)

0.689

≥60

61 (56.48)

0.0112

0.0012(0.0000-0.2350)

 

Gender

    

 Male

61 (56.48)

0.0117

0.0013(0.0000-0.2350)

0.228

 Female

47 (43.52)

0.0070

0.0010(0.0000-0.0787)

 

Location of tumor

    

 Head

72 (66.67)

0.0071

0.0010(0.0000-0.0842)

0.494

 Body and tail

36 (33.33)

0.0147

0.0015(0.0000-0.2350)

 

Size of tumor

    

≤2 cm

22 (20.37)

0.0074

0.0010(0.0000-0.0682)

0.647

>2 cm

86 (79.63)

0.0102

0.0011(0.0000-0.2350)

 

Nerve infiltration

    

 No

38 (35.19)

0.0098

0.0007(0.0000-0.0842)

0.137

 Yes

70 (64.81)

0.0096

0.0012(0.0000-0.2350)

 

Differentiation

    

 Well

15 (13.89)

0.0267

0.0012(0.0000-0.2350)

0.979

 Moderate

83 (76.85)

0.0071

0.0011(0.0000-0.0842)

 

 Poor

10 (9.26)

0.0055

0.0011(0.0001-0.0340)

 

TNMa staging

    

 IA + IB

15 (13.89)

0.0009

0.0006(0.0000-0.0040)

0.001*

 IIA

33 (30.56)

0.0056

0.0015(0.0001-0.0682)

 

 IIB

46 (42.59)

0.0069

0.0008(0.0000-0.0842)

 

 III + IV

14 (12.96)

0.0380

0.0076(0.0003-0.2350)

 

Serum CA19-9b level

    

 ≤39KU/l

31 (28.70)

0.0155

0.0009(0.0000-0.2350)

0.965

 >39KU/l

77 (71.30)

0.0073

0.0011(0.0000-0.8423)

 

Serum CA50c level

    

 ≤25KU/l

49 (45.37)

0.0152

0.0009 (0.0000-0.2350)

0.894

 >25KU/l

59 (54.63)

0.0050

0.0011(0.0000-0.0829)

 

Serum CEAd level

    

 ≤5 μg/l

64 (59.26)

0.0093

0.0010(0.0000-0.0842)

0.557

 >5 μg/l

44 (40.74)

0.0101

0.0011(0.0000-0.2350)

 
  1. TNMa, tumor-node-metastasis; CA19-9b, carbohydrate antigen 19–9; CA50c, carbohydrate antigen 50; CEAd, carcinoembryonic antigen; *P <0.05.