Table 1 TP53 and PIK3CA mutations and tumor clinical characteristics (n = 114)
TP53mutant | TP53wild type | Pvalue | PI3KCAmutant | PIK3CAwild type | Pvalue | |||||
|---|---|---|---|---|---|---|---|---|---|---|
(n = 23) | (n = 91) | (n = 6) | (n = 108) | |||||||
Variable | n | (%) | n | (%) | ||||||
Mean age [SD] | 48.7 | [±10.6] | 51.4 | [±14.7] | 0.326 | 56.9 | [±10.5] | 50.9 | [±14.5] | 0.364 |
Histology | 0.035* | 0.400** | ||||||||
Adenocarcinoma (n = 28) | 10 | (36) | 18 | (64) | 3 | (11) | 25 | (89) | ||
Squamous carcinoma (n = 55) | 9 | (16) | 46 | (84) | 3 | (5) | 52 | (95) | ||
CIN 3 (n = 31) | 4 | (13) | 27 | (87) | 0 | |||||
Grading*** | 0.603 | 0.664 | ||||||||
G1 (n = 5) | 0 | 0 | ||||||||
G2 (n = 23) | 7 | (30) | 16 | (70) | 1 | (4) | 22 | (96) | ||
G3 (n = 55) | 12 | (22) | 43 | (78) | 5 | (9) | 50 | (91) | ||
HPV status | ||||||||||
Negative (n = 37) | 10 | (27) | 27 | (73) | 4 | (11) | 33 | (89) | ||
Positive (n = 77) | 13 | (17) | 64 | (83) | 2 | (3) | 75 | (97) | ||