Figure 5

Knockdown of CK2α inhibited cell migration and invasion of CRC cell lines. (A) Monolayers of cells transfected with CK2α-specific siRNAs were wounded by scraping, and wound closure was followed at 0, 12, and 24 h. The distance of the wound was measured. Columns, mean of three independent experiments; bars, SD. *P < 0.01. (B) After transfection with CK2α-specific siRNAs for 18 h, cells that migrated through the filters were counted in five randomly selected fields. Columns, mean of three independent experiments; bars, SD. #P < 0.05.