Figure 2

Statistical evaluation of LC-MS peptide peak expression level differences. Volcano plot displaying intensity differences of peaks from LC-MS proteomic profiles of 10 replicate injections of a single plasma sample (green). The same analyses of the intensity differences of peaks from a comparison of LC-MS profiles of healthy volunteer and breast cancer patient volunteer plasma samples is also displayed (red balls, 20 discrete plasma samples in each group). The negative log2 scale is displayed for each axis: horizontal and vertical lines indicate fold change greater than 2 and p values < 0.05.