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Table 3 Phenotypic and functional markers of anti-CRC CTL007 and autologous WC007 tumor cell line

From: In vitro migration of cytotoxic T lymphocyte derived from a colon carcinoma patient is dependent on CCL2 and CCR2

Parameter investigateda

Cell lines (% cells positive)

 

CRC WC007

CTL007

HLA Class I

99.8

95.6

HLA Class II

< 1

60

CD4

NA

96

CD8

NA

< 1

CD25

< 1

30

CD40L

2.1

13

CD44

48

79.7

CD80 (B7-1)

85

< 1

CD49a (α1 integrin)

48.2

26.1

CD49b (α2 integrin)

63.2

32.5

CD29 (β1 integrin)

56.9

79.8

CD95 (FAS)

65.1

95.1

CD95L (FASL)

19

< 1

CD54 (ICAM-1)

84.5

89.3

CD11a (LFA-1a)

< 1

84.2

  1. NA = not applicable
  2. aAll markers were determined by flow cytometry and data represented are from a single experiment and the Results were confirmed in at least two independent experiments.
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Journal of Translational Medicine

ISSN: 1479-5876

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