Table 1 Correlation between expression of ERCC1 and clinicopathological factors of HNSCC
ERCC1 | P | Multivariates analysis | P | |||
|---|---|---|---|---|---|---|
No. of patients | Low expression | High expression | OR (95% CI) | |||
Age | ||||||
   ≦50 | 22 (38.6%) | 11 (50.0%) | 11 (50.0%) | 0.598 | 1 | |
   > 50 | 35 (61.4%) | 20 (57.1%) | 15 (42.9%) | 0.47 (0.11, 2.11) | 0315 | |
Gender | ||||||
   Male | 55 (96.5%) | 30 (54.5%) | 25 (45.5%) | 1.000 | 1 | |
   Female | 2 (3.5%) | 1 (50%) | 1 (50%) | 48.36 (0.54, 4313.32) | 0.090 | |
Tumor Site | ||||||
   oral cavity | 24 (42.1%) | 11 (45.8%) | 13 (54.2%) | 0.057 | 1 | |
   oropharynx | 21 (36.8%) | 10 (47.6%) | 11 (52.4%) | 1.58 (0.35, 7.07) | 0.549 | |
   hypopharynx/Larynx | 12 (21.1%) | 10 (83.3%) | 2 (16.7%) | 0.096 (0.007, 1.33) | 0.081 | |
Stage | ||||||
   IVa | 10 (17.5%) | 7 (70.0%) | 3 (30.0%) | 0.319 | 1 | |
   IVb | 47(82.5%) | 24 (51.1%) | 23 (48.9%) | 3.33 (0.39, 27.89) | 0.276 | |
T stage | ||||||
   1/2 | 6 (10.5%) | 6 (100%) | 0 (0%) | 0.027* | 1 | |
   3/4 | 51 (89.5%) | 25 (49.0%) | 26 (51.0%) | Indeterminate | 0.999 | |
N stage | ||||||
   negative | 12 (21.1%) | 5 (41.7%) | 7 (58.3%) | 0.503 | 1 | |
   positive | 45 (78.9%) | 26 (57.8%) | 19 (42.2%) | 0.75 (0.15, 3.64) | 0.727 | |
Alcohol drinking | ||||||
   Never | 11 (17.2%) | 4 (36.4%) | 7 (63.6%) | 0.318 | 1 | |
   Yes | 46 (82.8%) | 27 (58.7%) | 19 (41.3%) | 2.49 (0.31, 19.88) | 0.388 | |
Smoking | ||||||
   Never | 9 (15.8%) | 3 (33.3%) | 6 (66.7%) | 0.275 | 1 | |
   Yes | 48 (84.2%) | 28 (58.3%) | 20 (41.7%) | 1.77 (010, 30.72) | 0.695 | |
Betel nuts | ||||||
   Never | 20 (35.1%) | 8 (40.0%) | 12 (60.0%) | 0.109 | 1 | |
   Yes | 37 (64.9%) | 23 (62.2%) | 14 (37.8%) | 12.78 (1.28-127.62) | 0.030* | |