Figure 2
GCP activity in rat paw pads and sciatic nerve is inhibited by peripheral administration of 2-PMPA - Rats were treated with 2-PMPA (1, 10 and 100 mg/kg i.p.) as well as vehicle control. Animals were sacrificed 1 h after compound administration, paw pads and sciatic nerve isolated and GCP activity determined (Methods). (A): GCP activity ([3H]-glutamate production in dpm/10 mg tissue) in paw pads; * p < 0.05 (B): GCP activity in sciatic nerve. **p < 0.01.