Figure 4
From: Definition of the viral targets of protective HIV-1-specific T cell responses
Responses to OLP identified in multi-variate analysis are associated with reduced viral loads: Response patterns and HLA class I genetics in the clade B cohort in Lima and clade C cohort in Durban were subjected to FASS multivariat analysis [41–43]. Viral loads in individuals mounting zero vs. at least one response to beneficial OLP identified by the FASS multi-variate analysis were compared for (A) the Lima clade B cohort and the (B) Durban clade C cohort. The larger data set for the clade C cohort allowed for a further stratification of the responder group by increasing numbers of targeted OLP emerging from the FASS analysis (C). A gradually declining median viral load in relation to an increasing breadth of these responses was seen (ANOVA, p < 0.0001).