Figure 1

Ratios of infarct area to total coronal sectional area using TTC staining. ( A to E) Identification of gross infarct area (green circles) in animals with B) ischemic stroke (IS) (group 2), C) IS + cyclosporine (CsA) (group 3), D) IS + erythropoietin (EPO) (group 4) and E) IS + combined CsA & EPO (group 5), respectively. (F) Significantly lower ratio of infarct area to total coronal sectional area in group 5 than in group 2, 3, and 4, and notably lower in group 3 and 4 than in group 2 (n = 6 for each group). * vs. other groups, p < 0.0001 (using ANOVA). Symbols (*, †, ‡) indicate significance (at 0.05 level) (by Scheffe multiple-comparison post hoc test).