Table 2 Obesity-related anthropometric measurements and metabolic components in moderately-severely obese females, grouped according to hepatic steatosis score at ultrasound (US) and in normal-weight controls matched for age and sex
From: Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females
Hepatic steatosis score at US | p values | ||
|---|---|---|---|
0-1 score (21/48) | 2-3 grade (27/48) | ||
Age(years) | 40.6 ± 14.7 | 40.6 ± 12.3 | NS |
BMI | 32.7 ± 5.8 | 37.4 ± 5.8 | NS |
Waist circumference(cm) | 107.8 ± 17.3 | 113.0 ± 14.9 | NS |
Fat mass % | 35.7 ± 8.0 | 43.6 ± 6.0 | < 0.001 |
FPG (mg/dl) | 92.8 ± 14.2 | 92.5 ± 8.4 | NS |
FPI (μU/ml) | 10.7 ± 5.3 | 17.6 ± 10.7 | 0.021 |
HOMA | 2.5 ± 1.5 | 4 ± 2.5 | 0.037 |
Total cholesterol (mg/dl) | 197.0 ± 30.9 | 201.9 ± 33.3 | NS |
HDL- cholesterol (mg/dl) | 58.2 ± 29 | 49.8 ± 9.3 | NS |
Triglycerides (mg/dl) | 111.7 ± 60.8 | 137.8 ± 81 | NS |
SBP (mmHg) | 129.5 ± 17.2 | 130.4 ± 18.0 | NS |
DBP (mmHg) | 84.6 ± 8.7 | 84.5 ± 11.5 | NS |
AST (U/L) | 21.6 ± 6.0 | 26.2 ± 18.5 | NS |
ALT (U/L) | 25.2 ± 10.8 | 49.9 ± 21.6 | 0.045 |
Uric acid (mg/dl) | 4.4 ± 1.0 | 4.5 ± 1.1 | NS |
CRP (mg/dl) | 1.9 ± 2.1 | 3.6 ± 3.0 | 0.04 |
SLD (mm) | 108.5 ± 10.5 | 124.2 ± 13.7 | 0.004 |
AST/platelet ratio index | 0.44 ± 3.2 | 0.47 ± 2.5 | NS |
IGF-I (μg/l) | 203.8 ± 94.8 | 138.0 ± 54.0 | 0.004 |
IGF-I zSDS | -1.2 ± 1.8 | -2.5 ± 1.5 | 0.08 |
IGFBP-1 | 16.0 ± 3.7 | 12.8 ± 2.5 | 0.03 |
IGFBP-3 (ng/ml) | 4526.8 ± 1321.8 | 4311.5 ± 1325.8 | NS |
IGF-I/IGFBP3 ratio | 0.032 ± 0.01 | 0.023 ± 0.01 | 0.002 |