Figure 3
From: Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats
Blockage of oxygen consumption by Atractyloside (Atr). In normal conditions, Atr competes with ADP in ANT blocking oxygen consumption. In this case, Atr was not able to block oxygen consumption in mitochondria from untreated aging rats, suggesting an uncoupling of the ANT probably caused by oxidation of ANT-thiol groups [18, 19]. In this condition of mitochondrial oxidative damage, respiration is Atr insensitive.