Journal of Translational Medicine

Table 1 Prognostic clinicopathological variables as predictors for disease-specific survival in patients with completely resected non-gastrointestinal stromal tumor soft-tissue sarcomas (univariate analyses, log rank test; multivariate analysis, Cox regression analysis)

From: Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients

	Univariate analyses					Multivariate analysis
Characteristics	Patients (n)	Patients (%)	Median survival (months)	5-Year survival (%)	P	HR	95% CI	P
Age
≤ 20 years	7	7	NR	57	0.960
21-60 years	55	51	NR	64
> 60 years	46	43	NR	60
Gender
Male	47	44	NR	74	0.054
Female	61	56	127	53
Patient nationality
Norwegian	73	68	NR	73	< 0.001	1.000
Russian	35	32	22	38		2.777	1.457-5.292	0.002
Histological entity
Pleomorphic sarcoma	29	27	54	50	0.127
Leiomyosarcoma	34	32	68	53
Liposarcoma	13	12	NR	92
Fibrosarcoma	8	7	NR	88
Angiosarcoma	5	5	NR	60
Rhabdomyosarcoma	6	6	NR	67
MPNST	5	5	NR	80
Synovial sarcoma	6	6	59	80
Sarcoma NOS	2	2	NR	100
Tumor localization
Extremities	46	43	NR	66	0.735
Trunk	21	19	NR	60
Retroperitoneum	7	7	NR	71
Head/Neck	4	4	NR	75
Visceral	30	28	63	53
Tumor size
≤ 5 cm	40	37	NR	75	0.262
5-10 cm	46	43	NR	53
> 10 cm	20	18	NR	60
Missing	2	2
Malignancy grade								0.015*
1	32	30	NR	90	< 0.001	1.000
2	36	33	NR	61		3.808	1.084-13.380	0.037
3	40	37	32	39		5.937	1.721-20.481	0.005
Tumor depth
Superficial	12	11	**	**	0.009	**	**	**
Deep	96	89		57
Metastasis at diagnosis
No	97	90	218	66	< 0.001	1.000
Yes	11	10	8	27		4.689	2.004-10.972	< 0.001
Chemotherapy
No	79	73	NR	65	0.234
Yes	29	27	120	55
Radiotherapy
No	87	81	NR	63	0.375
Yes	21	19	NR	57

Abbreviations: NR, not reached; MPNST, malignant peripheral nerve sheath tumor; NOS, not otherwise specified; *, overall significance as a prognostic factor; **all cases were censored.

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ISSN: 1479-5876

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