Table 1 Main characteristics of the patients with HCM and hypertensive LVH
Total HCM (n = 245) | Familial HCM (n = 105; 43%) | Sporadic HCM* (n = 140; 57%) | Hypertensive LVH (n = 145) | |
|---|---|---|---|---|
Mean age at Diagnosis (years) | 46 ± 13 | 37 ± 18 | 43 ± 19 | 58 ± 17 |
Range | 8-76 | 8-72 | 21-76 | 35-75 |
Male | 144 (59%) | 68 (65%) | 76 (56%) | (59%) |
Mean BMI | ||||
Male | 27 ± 3 | 26 ± 3 | 27 ± 4 | 28 ± 4 |
Female | 26 ± 4 | 25 ± 3 | 26 ± 3 | 28 ± 5 |
Mean IVS# | 20 ± 5 | 22 ± 6 | 18 ± 7 | 15 ± 5 |
Mean PWT# | 13 ± 5 | 14 ± 5 | 11 ± 6 | 10 ± 6 |
Mean LVWT# | 34 ± 6 | 36 ± 6 | 30 ± 6 | 26 ± 6 |
Dyspnea | 168 (69%) | 78 (74%) | 90 (64%) | 30% |
NYHA index# | ||||
Class I-II | 120 (49%) | 49 (47%) | 71 (51%) | 85% |
Class III-IV | 48 (20%) | 29 (28%) | 19 (14%) | 15% |
Angina | 96 (39%) | 53 (50%) | 43 (31%) | 16% |
Syncope | 48 (20%) | 25 (24%) | 23 (16%) | 6% |
Atrial fibrillation | 47 (19%) | 23 (22%) | 24 (17%) | 15% |
Arrhythmia (Holter monitoring) | 55 (22%) | 21 (20%) | 34 (24%) | 18% |
LVOT > 30 mm Hg# | 72 (29%) | 34 (32%) | 38 (27%) | 30% |
Sarcomeric mutations | 40 (16%) | 30 (29%) | 10 (7%) | ND |
MYH7 | 12 (5%) | 11 (10%) | 1(< 1%) | |
MYBPC3 | 23 (9%) | 16 (15%) | 7(5%) | |
TNNT2 | 4 (2%) | 2 (2%) | 2 (1%) | |
TPM1 | 1 (< 1%) | 1 (1%) | 0 |