Table 5 rhIL21 induced IL2RA expression in whole blood from cynomolgus monkeys dosed with Ab-01
Animal | Treatment Group | Time point | Ex vivoIL2RA Fold Change Response to IL21 Stimulation | Cpeak |
|---|---|---|---|---|
1 | Ab-01 | pre-dose | 2.8 | not applicable |
1 | Ab-01 | 5 minute post dose | 0.8 | 200 |
2 | Ab-01 | pre-dose | 4.8 | not applicable |
2 | Ab-01 | 5 minute post dose | 0.8 | 139 |
3 | Ab-01 | pre-dose | 4.2 | not applicable |
3 | Ab-01 | 5 minute post dose | 0.9 | 153 |
4 | Control IgG1TM | pre-dose | 4.2 | not applicable |
4 | Control IgG1TM | 5 minute post dose | 4.3 | not applicable |
5 | Control IgG1TM | pre-dose | 2.7 | not applicable |
5 | Control IgG1TM | 5 minute post dose | 4.4 | not applicable |
6 | Control IgG1TM | pre-dose | 9.1 | not applicable |
6 | Control IgG1TM | 5 minute post dose | 7.7 | not applicable |