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Table 2 Assays used to measure monkey genes on custom TaqMan low density array for monkey studies

From: Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

Gene ID

Use

Species

Assay ID (ABI)

18S

Manufacturing QC

Human

Hs99999901_s1

CD19

Effects of IL21/Ab-01

Human

Hs00174333_m1

CSF1

Effects of IL21/Ab-01

Human

Hs00174164_m1

GUSb

Normalizer

Human

Hs99999908_m1

GZMB

Effects of IL21/Ab-01

Rhesus

Rh02621701_m

ICOS

Effects of IL21/Ab-01

Rhesus

Rh02621771_m1

IFN γ

Effects of IL21/Ab-01

Rhesus

Rh02621721_m1

IL10

Effects of IL21/Ab-01

Human

Hs00174086_m1

IL12B

Effects of IL21/Ab-01

Human

Hs00233688_m1

IL21R

Effects of IL21/Ab-01

Human

Hs00174086_m

IL2RA

Effects of IL21/Ab-01

Human

Hs00166229_m1

IL6

Effects of IL21/Ab-01

Rhesus

Rh02621719_u1

IL7

Effects of IL21/Ab-01

Human

Hs00174202_m1

IL8

Effects of IL21/Ab-01

Human

Hs00174103_m1

PGK1

Normalizer

Human

Hs99999906_m1

PRF1

Effects of IL21/Ab-01

Human

Hs00169473_m1

STAT3

Effects of IL21/Ab-01

Human

Hs00234174_m1

TBX2

Effects of IL21/Ab-01

Human

Hs00203436_m1

TNF

Effects of IL21/Ab-01

Human

Hs00174128_m1

ZNF592

Normalizer

Human

Hs00206029_m1

  1. In addition to the assays listed, assays for CCL19, CSF2, IL-17, and REN were run but found to be unreliable in these cynomolgus monkey samples and are not shown.