Figure 2

Whole human blood response to ex vivo stimulation with 10 ng/mL rhIL21 for 2 hours. Data shown are for the 6 genes (of 19 tested) with the most consistent response among the 9 individual donors, and are identified as 6 preferred biomarkers of rhIL21 activity in whole human blood. These 6 genes were also identified as the best indicators of IL21 response in a series of pilot studies conducted with blood from a different group of donors (data not shown).