Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients

Table 4 Genes up- or down-regulated in IPC patients compared to control patients at 1 hour into surgery (t = 1)

Gene name	Gene symbol	Public ID	Fold change	P
Immediate early genes
Early growth response 1	EGR1	AV733950	2.84	0.001
Myc proto oncogene protein	MYC	NM_002467	2.58	0.038
Cellular oncogene c-fos	FOS	BC004490	2.11	0.018
Immediate early response 2	IER2	NM_004907	1.58	0.034
Jun oncogene	JUN	BC002646	1.43	0.001
Oxidative stress defence
Catalase	CAT	AU147084	2.14	0.017
Glutathione S-transferase theta 1	GSTT1	AL359937	2.69	0.025
Sequestosome 1	SQSTM1	AW293441	2.04	0.018
Chaperone/Survival
DnaJ (Hsp40) homolog, subfamily B, member 6	DNAJB6	AF080569	1.45	0.042
Heat shock 22 kDa protein 8	HSPB8	BF109740	1.83	0.001
BCL2/adenovirus E1 B 19 kDa interacting protein 1	BNIP1	NM_013979	1.50	0.004
BCL6 co-repressor	BCOR	AF317391	1.74	0.047
Anti-apoptotic
Caspase 8	CASP8	BF439983	-2.00	0.045
Caspase 7	CASP7	NM_001227	-1.31	0.026
Mitochondrial
Uncoupling protein 3	UCP3	NM_003356	2.41	0.001
Pyruvate dehydrogenase kinase 4	PDK4	AL832708	2.99	0.009

* A positive number indicates elevated expression (fold change) in skeletal muscle tissue of IPC-treated patient compared to skeletal muscle tissue of control patient. A negative number indicates decreased expression (fold change) in skeletal muscle tissue of IPC-treated patient compared to skeletal muscle tissue of control patient.

ISSN: 1479-5876