| Arm A (n = 35) | Arm B (n = 35) |  | Arm A (n = 35) | Arm B (n = 35) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Grade | Grade |  | Grade | Grade | ||||||||
Toxicity Type | 1, 2 | 3 | 4 | 1, 2 | 3 | 4 | Toxicity Type | 1, 2 | 3 | 4 | 1, 2 | 3 | 4 |
Allergic reaction | - | - | - | - | 2 | - | Stomatitis | 5 | - | - | 6 | 1 | - |
Allergic rhinitis | 1 | - | - | 1 | - | - | Taste disturbance | 6 | - | - | 4 | - | - |
Hemoglobin | 31 | 3 | 1 | 28 | 5 | - | Vomiting | 10 | - | - | 9 | 1 | - |
Leukocytes | 9 | 18 | 8 | 22 | 4 | 2 | Diarrhea | 5 | 2 | - | 11 | - | - |
Neutrophils | 4 | 11 | 18 | 16 | 7 | 2 | GI-other | 2 | - | - | - | - | - |
Platelets | 20 | 5 | - | 13 | 1 | - | Hematuria | - | 1 | - | 1 | - | - |
Transfusion: | - | 1 | - | - | 4 | - | Rectal bleeding | - | - | - | - | 1 | - |
Sinus tachycardia | - | 1 | - | - | 1 | - | Alkaline phos | 13 | 2 | - | 15 | 3 | - |
Supraventricular | - | - | - | - | 1 | - | Bilirubin | 1 | 1 | 1 | 5 | - | - |
Cardiac-ischemia | - | - | - | 1 | - | - | Hypoalbuminemia | - | - | - | 1 | - | - |
Cardiac-left vent | - | 1 | - | - | - | - | SGOT | 7 | - | - | 10 | 1 | - |
Edema | 9 | - | - | 4 | - | - | SGPT | 6 | - | - | 7 | 1 | - |
Hypertension | 2 | - | - | 1 | - | - | Febrile neutropenia | - | 4 | - | - | 1 | - |
Hypotension | 1 | - | - | 3 | - | - | Infection w/neutro | - | 1 | 1 | - | - | - |
Phlebitis | 1 | - | - | - | - | - | Infectionw/oneutro | 2 | Â | - | 1 | 1 | - |
Thrombosis/emb | - | 6 | 1 | - | 1 | - | Hypercalcemia | 1 | - | - | 1 | - | - |
Fatigue | 21 | 7 | 1 | 23 | 7 | 1 | Hyperglycemia | 2 | 1 | - | 3 | 1 | - |
Fever | - | - | - | 7 | 1 | - | Hyperkalemia | 1 | - | - | 1 | - | - |
Rigors/chills | 1 | - | - | 10 | - | - | Hypertrig | 6 | - | - | 22 | 1 | - |
Sweating | - | - | - | 2 | - | - | Hyponatremia | 1 | - | - | 1 | - | - |
Weight gain | 1 | - | - | - | - | - | Metabolic-other | 1 | - | - | - | - | - |
Weight loss | 14 | - | - | 7 | 2 | - | Muscle weakness | 1 | - | - | - | 1 | - |
PTT | - | 1 | - | - | - | - | Ataxia | - | - | - | 1 | - | - |
PT | 1 | 1 | - | - | - | - | Dizziness | 3 | - | - | 3 | - | - |
Alopecia | 8 | - | - | 11 | - | - | Hallucinations | - | - | - | - | 1 | - |
Bruising | 2 | - | - | - | - | - | Insomnia | 2 | - | - | 7 | - | - |
Dry skin | 1 | - | - | 3 | - | - | Depression | 4 | 1 | - | 2 | - | - |
Flushing | - | - | - | 3 | - | - | Euphoria | 1 | - | - | - | - | - |
Injection site | 2 | - | - | - | - | - | Neuropathy-motor | 2 | - | - | 1 | - | - |
Pruritus | 2 | - | - | - | - | - | Neuro-sensory | 6 | - | - | 9 | - | - |
Rash | 4 | - | - | 2 | - | - | Vertigo | 1 | - | - | - | - | - |
Skin-other | 2 | - | - | - | - | - | Neurologic-other | 1 | - | - | - | - | - |
Gynecomastia | 3 | - | - | - | - | - | Tearing | 1 | - | - | - | - | - |
Hot flashes | 3 | - | - | 1 | - | - | Blurred vision | 1 | - | - | 3 | - | - |
Endocrine-other | - | - | - | 1 | - | - | Abdominal pain | 2 | - | - | - | - | - |
Anorexia | 16 | 1 | - | 14 | 2 | - | Arthralgia | 2 | - | - | 3 | - | - |
Constipation | 12 | 1 | - | 8 | - | - | Bone pain | 1 | - | - | 5 | - | - |
Dehydration | - | 1 | - | 2 | 1 | - | Chest pain | 1 | - | - | - | - | - |
Dyspepsia | 3 | - | - | - | - | - | Headache | 2 | - | - | 8 | - | - |
Dysphagia | 1 | - | - | 1 | - | - | Myalgia | 4 | - | - | 11 | - | - |
Flatulence | 1 | - | - | 1 | - | - | Pain-other | 2 | - | - | - | - | - |
Mouth dryness | - | - | - | 3 | - | - | Cough | 5 | - | - | - | - | - |
Nausea | 21 | - | - | 18 | 1 | - | Dyspnea | 7 | - | 1 | 11 | 1 | - |
Sense of smell | 1 | - | - | - | - | - | Hypoxia | - | - | - | - | 1 | - |
Creatinine/GU | 8 | - | 1 | 3 | - | 2 | Pulmonary-other | - | - | - | 3 | 1 | - |