Table 2 Sensitivity of human DCs to the cytotoxic effects of antineoplastic chemotherapeutic agents in vitro
Chemotherapeutic agent (concentration, nM) | Apoptosis of DCs (% ± SEM) |
|---|---|
vinblastine (50) | 3.2 ± 0.9 |
vinblastine (10) | 1.1 ± 1.3 |
vinblastine (1) | 0.9 ± 0.3 |
vinblastine(0.1) | -0.6 ± 0.3 |
vincristine (50) | 6.5 ± 2.1 |
vincristine (10) | 3.3 ± 1.9 |
vincristine (1) | 0.5 ± 0.6 |
vincristine (0.1) | -0.6 ± 0.9 |
paclitaxel (25) | 4.9 ± 2.3 |
paclitaxel (5) | 2.2 ± 0.7 |
paclitaxel (1) | 2.2 ± 0.4 |
paclitaxel (0.1) | 0.1 ± 0.3 |
5-aza-2deoxycitidine (25) | 7.4 ± 3.3 |
5-aza-2deoxycitidine (5) | 0.8 ± 0.8 |
methotrexate (25) | 3.9 ± 1.1 |
methotrexate (5) | 0.8 ± 0.6 |
methotrexate (1) | 0.3 ± 0.4 |
mitomycin C (25) | 1.3 ± 1.4 |
mitomycin C (5) | -0.9 ± 0.4 |
doxorubicin (100) | 5.5 ± 0.9 |
doxorubicin (25) | 3.4 ± 0.3 |
doxorubicin (5) | 0.6 ± 1.8 |