Table 1 Physical properties of PAMAM and Gd-PAMAM dendrimers
From: Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors
Dendrimer generation (G) | Terminal amines (#) | Naked PAMAM molecular weight # (kDa) | Gd-PAMAM dendrimer molecular weight (kDa) | Gd-DTPA conjugation (%) | Molar relaxivity&(1/mM*s) |
|---|---|---|---|---|---|
G5 | 128 | 29 | 79†| 52 | 9.81 |
G6 | 256 | 58 | 138†| 45 | 10.04 |
G7 | 512 | 116 | 283‡ | 43 | 9.82 |
G8 | 1024 | 233 | 490‡ | 36 | 10.05 |