Table 4 Selected series analyzing the prognostic role of circulating tumor cells (CTC) in patients with gastric cancer.
Author | Year | Ref. | Patients | Method | Survival analysis | Markers | Findings |
|---|---|---|---|---|---|---|---|
Koga T et. al. | 2008 | [9] | 101 | Quantitative RT-PCR | Univariate | CK18, CK19, CK20, CEA | CK19 is the better marker, and is usable to estimate prognosis or for adjuvant treatment |
Yie SM et. al. | 2008 | [20] | 26 (gastric cancer) | RT-PCR ELISA | Multivariate | Survivin | Status of Survivin-expressing CTC is a strong and independent predictor for recurrence |
Hiraiwa K et. al. | 2008 | [22] | 44 (gastric cancer) | CellSearch system | Multivariate | CD45 (-) cells vs CK (+) cells | CTSs significantly correlated with advanced tumor stage |
Illert B et. al. | 2005 | [23] | 70 | Quantitative RT-PCR | Multivariate | CK20 | CK20 is an independent prognostic marker |
Yeh KH et. al. | 1998 | [24] | 34 | Nested quantitative RT-PCR | Univariate | CK19 | CK19 expressing CTC are associated with poor prognosis |
Seo JH et. al. | 2005 | [25] | 46 | Quantitative RT-PCR | Not performed | CEA | CEA mRNA is significantly correlated with clinical recurrence |
Wu CH et. al. | 2006 | [26] | 42 | Quantitative RT-PCR | Not performed | hTERT, CK19, CK20, CEA | CEA mRNA is correlated with higher risk of postoperative recurrence/metastasis |
Uen YH et. al. | 2006 | [27] | 52 | Quantitative RT-PCR | Univariate | c-MET, MUC1 | c-Met and MUC1mRNA significantly correlate with prognosis |
Mimori K et. al. | 2008 | [28] | 810 | Quantitative RT-PCR | Univariate | MT1-MMP | MT1-MMP is an independent factor for determining recurrence and distant metastasis |
Pituch-Noworolska A et. al. | 2007 | [29] | 57 | Flow cytometry | Univariate | CD45 (-) cells vs CK (+) cells | The presence of CK (+) cells is of no prognostic value |