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Table 3 Univariate and multivariate Cox proportional hazard models fit on 21 tumor markers.

From: Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosis

Tumor Marker

p* <

HR†

p‡ <

HR§

CEA

0.00019

1.54 (1.23 - 1.93)

0.0007

1.55 (1.21 - 2.05)

CA125

0.0014

1.45 (1.16 - 1.83)

0.0025

1.43 (1.14 - 1.80)

EGFR

0.089

2.17 (0.89 - 5.30)

0.12

2.16 (0.81 - 5.75)

CPA1

0.13

1.33 (0.92 - 1.94)

0.023

1.54 (1.06 - 2.24)

ERBB2

0.24

1.31 (0.84 - 2.03)

0.0023

1.84 (1.23 - 2.76)

ADAM8

0.26

1.20 (0.87 - 1.66)

0.51

1.12 (0.80 - 1.58)

CA15-3

0.27

1.33 (0.80 - 2.20)

0.3

1.33 (0.77 - 2.30)

SLPI

0.27

1.32 (0.80 - 2.15)

0.005

1.86 (1.21 - 2.87)

MIF

0.31

0.88 (0.68 - 1.13)

0.36

0.88 (0.67 - 1.16)

Galectin

0.34

1.33 (0.74 - 2.41)

0.36

1.35 (0.72 - 2.55)

IGF2

0.37

1.25 (0.77 - 2.02)

0.042

1.63 (1.02 - 2.62)

MESO

0.42

1.18 (0.79 - 1.74)

0.062

1.45 (0.98 - 2.16)

CTGF

0.45

1.09 (0.88 - 1.34)

0.98

1.00 (0.78 - 1.27)

TNF

0.47

1.13 (0.82 - 1.56)

0.17

1.25 (0.91- 1.71)

VEGF

0.58

0.94 (0.74 - 1.19)

0.65

0.94 (0.73- 1.22)

IL-7

0.58

0.95 (0.78 - 1.15)

0.52

0.93 (0.75 - 1.16)

EpCAM

0.61

1.07 (0.83 - 1.37)

0.35

1.14 (0.86 - 1.52)

CA19-9

0.67

1.04 (0.88 - 1.23)

0.86

0.98 (0.82 - 1.18)

OPN

0.68

1.10 (0.71 - 1.69)

0.58

0.87 (0.54 - 1.41)

IL-1

0.85

0.97 (0.74 - 1.28)

0.42

0.88 (0.65 - 1.19)

CHI3L1

0.94

0.99 (0.78 - 1.27)

0.91

0.99 (0.76 - 1.28)

  1. *- p-value derived from a univariate Cox proportional hazards model accounting for the effect of tumor marker only on prognosis
  2. † - Hazard ratio derived from univariate Cox proportional hazards model. Parenthetical values denote 95% confidence interval.
  3. ‡ - p-value derived from a multivariate Cox proportional hazards model accounting for tumor marker, sex, and therapy on prognosis
  4. §- Hazard ratio derived from multivariate Cox proportional hazards model. Parenthetical values denote 95% confidence interval.