Dendrimer generation (G) | No. terminal amines | Naked PAMAM molecular weight# (kD) | Gd-PAMAM molecular weight†(kD) | Gd-DTPA conjugation (%) | Molar relaxivity&(s/mM) |
---|---|---|---|---|---|
G1 | 8 | 1.43 | 5.63 | 67.1 | 9.8 |
G2 | 16 | 3.26 | 11.2 | 65.9 | 10.1 |
G3 | 32 | 6.91 | 18.6 | 47.7 | 10.4 |
Lowly conjugated G4 | 64 | 14.2 | 24.4 | 29.8 | 7.8 |
Standard G4 | 64 | 14.2 | 39.8 | 47.5 | 12.2 |
G5 | 128 | 28.8 | 79.8 | 47.2 | 10.9 |
G6 | 256 | 58.0 | 133 | 39.9 | 10.6 |
G7 | 512 | 116 | 330‡ | 50.0 | 10.3 |
G8 | 1024 | 233 | 597‡ | 37.8 | 9.4 |