From: Ex Vivo Metrics™, a preclinical tool in new drug development
Organs | Blood Input | Acceptance Criteria | Dosing Routes | Samples for Analysis |
---|---|---|---|---|
Lungs | • Pulmonary artery • Bronchial artery | • Perfusion pressures • Flow rates • Compliance • Resistance • Airway pressures • Blood chemistry and biochemistry | • Airways • Blood | • Blood/plasma • Airway lavage • Biopsies |
Liver | • Portal vein • Hepatic artery | • Perfusion pressures • Flow rates • Bile flow • Blood chemistry and biochemistry | • Blood | • Blood/plasma • Bile • Biopsies |
Intestine | • Superior mesenteric artery (or its branches) | • Perfusion pressure • Flow rate • Active peristalsis • Blood chemistry and biochemistry | • Gut lumen • Blood | • Blood/plasma • Gut contents • Biopsies |