Figure 6

Red blood cell recovery profiles for vehicle, G-CSF, IL-12 pre-only, IL-12 post-only and IL-12 pre-post treatment groups following chemotherapy. Red blood cell recovery profiles are shown for the EL4 tumor model in (A) and the Lewis lung cancer model in (B). Pre-chemotherapy blood values reflect an average of all animals in both groups (80 mice) before cyclophosphamide and tumor inoculation. The normal threshold value for murine red blood cell counts is indicated. EL4 mice received a cyclophosphamide dose of 250 mg/kg and the LL mice received a cyclophosphamide dose of 225 mg/kg. IL-12 treated mice received a total dose of 50 ng (pre-only) and 150 ng (post-only and pre-post (pre-post dose was split 50 ng before and 100 ng after cyclophosphamide)), whereas G-CSF treated mice received a total dose 1.5 μg.