Table 5 Multivariate Cox proportional hazards regression model for the primary outcome in women without obstructive CAD*
Factor | HR (95%CI) | P |
|---|---|---|
Clinical Model with Genetic Biomarkers (n = 396) | ||
ADRB1 Gly389 carrier | 1.71 (0.91–3.19) | 0.09 |
ADRB3 Arg64 carrier | 2.14 (1.06–4.30) | 0.03 |
Black race | 1.77 (0.90–3.48) | 0.10 |
Age (per decade) | 1.02 (0.99–1.05) | 0.25 |
History of diabetes | 4.08 (2.01–8.28) | < 0.001 |
Ever-smoking | 8.13 (3.55–18.63) | < 0.001 |
Baseline systolic BP (per 10 mmHg) | 1.16 (0.99–1.36) | 0.06 |
Body mass index (per 5 kg/m2) | 0.70 (0.54–0.92) | 0.01 |
Clinical Model with Inflammatory and Genetic Biomarkers (n = 355) | ||
ADRB1 Gly389 carrier | 1.67 (0.85–3.27) | 0.13 |
ADRB3 Arg64 carrier | 2.43 (1.11–5.35) | 0.03 |
Black race | 1.84 (0.92–3.67) | 0.08 |
Age (per decade) | 1.01 (0.97–1.04) | 0.66 |
History of diabetes | 3.78 (1.78–8.02) | < 0.001 |
Ever-smoking | 7.43 (3.13–17.63) | < 0.001 |
Baseline systolic BP (per 10 mmHg) | 1.17 (0.98–1.37) | 0.08 |
Body mass index (per 5 kg/m2) | 0.70 (0.53–0.93) | 0.01 |
1 inflammatory biomarker in upper quartile* | 1.67 (0.75–3.77) | 0.21 |
2 or 3 inflammatory biomarkers in upper quartile | 4.30 (2.02–9.16) | < 0.001 |