Endometrial regenerative cells: A novel stem cell population

Table 1 Phenotypic Characterization of ERC

Marker	Relevance	Expression
CD14	Monocyte marker	Negative
CD34	Hematopoietic stem cell marker	Negative
CD38	Differentiating hematopoietic stem cell marker	Negative
CD45	Pan-leukocyte marker	Negative
CD133	Hematopoietic/angioblast marker	Negative
STRO-1	MSC marker	Negative
SSEA-4	Embryonic stem cell marker	Negative
Nanog	Embryonic stem cell marker	Negative
CD9	MSC marker, associated with angiogenesis¹	Positive
CD29	Adhesion molecule on mesenchymal and hepatic stem cells²	Positive
CD59	Complement inhibitor protein found on MSC³ and bone marrow side population CD34-stem cells⁴	Positive
CD73	Ecto-5'-nucleotidase, involved in migration of MSC	Positive
CD41a	Receptor for fibrinogen and vWF, found on MSC and platelets	Positive
CD44	Hyaluronic acid receptor found on tissue stem cells and MSC	Positive
CD90	Marker of T cells, hematopoietic and MSC	Positive
CD105	Marker of tissue and MSC	Positive
hTERT	Telomerase reverse transcriptase	Positive
Oct-4	Embryonic stem cell marker	Positive

¹ Kim YJ, Yu JM, Joo HJ, Kim HK, Cho HH, Bae YC, Jung JS. Role of CD9 in proliferation and proangiogenic action of human adipose-derived mesenchymal stem cells. Pflugers Arch. 2007 Aug 1.
² Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi H, Nakano M, Zen Y, Nakanuma Y, Nakauchi H, Iwama A, Taniguchi H. Enhanced Self-Renewal Capability in Hepatic Stem/Progenitor Cells Drives Cancer Initiation. Gastroenterology. 2007 Jun 20;
³ Izadpanah R, Joswig T, Tsien F, Dufour J, Kirijan JC, Bunnell BA. Characterization of multipotent mesenchymal stem cells from the bone marrow of rhesus macaques. Stem Cells Dev. 2005 Aug;14(4):440–51.
⁴ Preffer FI, Dombkowski D, Sykes M, Scadden D, Yang YG. Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization. Stem Cells. 2002;20(5):417–27.

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