Figure 5From: CD39 activity correlates with stage and inhibits platelet reactivity in chronic lymphocytic leukemiaPlatelet reactivity to ADP with and without addition of CLL cells. Platelet function tests were performed on platelets from six patients with CLL. Evidence of platelet hyper-reactivity with increased area under the curve (AUC) and little decrement in platelet response to ADP from 10 μM to 2 μM was seen in three out of six patients. Some decrease in platelet reactivity was seen in all patients when 5 × 105-106 CLL cells were added to PRP and PPP. However, the decrease was minimal in one patient. P = 0.02 for 5 μM concentration, p = 0.1 for all other concentrations. However, data is partial for all concentrations except 5 μM. Of the six patients tested, four were stage 0, one stage 2, and one stage 3 disease. All had platelet counts of greater than 150 K.Back to article page