From: Tumor-specific T cells signal tumor destruction via the lymphotoxin β receptor
Adoptive immunotherapy a | Mean number of pulmonary metastases b | ||||||
---|---|---|---|---|---|---|---|
Donor | Hosts | Number of T cells transferred | Blocking proteinsb | Exp.1 | Exp.2 | Exp.3 | Exp.4 |
None | wt | 0 | none | 250 | 250 | ||
wt | wt | 35 | hu IgG | 21(5)d | 52(13)d | ||
wt | wt | 35 | LTβR-Fc | 33(6)d | 78(11)d | ||
wt | GKO | 0 | None | 243(60) | 244(60) | 250 | 250 |
GKO | GKO | 35 | hu IgG | 6(3)d | 88(23)d | 85(12)d | 90(30)d |
GKO | GKO | 35 | LTβR-Fc | 9(3)d | 211(56)e | 250e | 250e |