Figure 1

Genes differentially expressed between pre and post wound skin biopsies. One skin punch biopsy was obtained pre wound and one either day 2, 4, or 8 post wound from 14 subjects. The 1,749 genes found to be differentially expressed using paired t-test comparison (p < 0.05) were analyzed by filtering (genes expressed in 80% of samples and at least more increased 2 or more fold) and this yielded 753 genes. Supervised hierarchical clustering analysis of Eisen of the 753 differentially expressed genes revealed 7 signature clusters (Figure 1a). The genes in the 7 clusters were combined and analyzed again by supervised hierarchical clustering (Figure 1b). The pre wound biopsies are indicated by the blue bar, the day 2 post wound biopsies by the yellow bar, the day 4 post wound biopsy by the purple bar, and the day 8 post wound biopsy by the orange bar (Figure 1c).