Disaggregation and invasion of ovarian carcinoma ascites spheroids

Table 1 Patient information.

Patient #	2	3	4	5	6	8	9	10
Diagnosis	Poorly differentiated papillary serous adenocarcinoma	Papillary serous adenocarcinoma	Primary peritoneal carcinoma with invasive implants	Poorly differentiated serous papillary carcinoma	Serous papillary carcinoma	Serous papillary carcinoma	Metastatic serous adenocarcinoma	Poorly differentiated adenocarcinoma
Stage	IIIC	IIIC	IIIC	IIIC	IIIC	IIIC	IIIC	IV
Grade	3	2	2	3	3	2	3	3
Initial CA125	860	168	1950	2800	366	640	191	6640
Debulking	optimal	optimal	optimal	suboptimal		optimal	optimal	optimal
Treatment	6 cycles Carbo/Taxol	6 cycles Carbo/Taxol	CDDP/Taxol	Failed several chemos: Taxol, Carbo, Gemzar	Taxol/Carbo 1 cycle	4 drugs/8 cycles	6 cycles (x2) Carbo/Taxol,	6 cycles Carbo/Taxol
Surgery to Recurrence (Months)	22	36	8	Progressive disease	Progressive disease	11	18	14
Overall Survival (Months)	39	Alive with disease	16	17	1	Alive with disease	Alive	34
Age at diagnosis	58	45	63	70	75	29	70	52
Family History	Aunt-breast cancer	Mother-ovarian, breast cancer; maternal grandmother-breast cancer; aunt-breast cancer				Mother-ovarian cancer; paternal aunt (x2)-breast cancer; maternal great aunt-gynecological cancer	Sister-breast cancer	Grandmother-uterine cancer; aunt-breast cancer; great aunt (x4)-gynecological cancer; grandmother-ovarian cancer

Patient data was obtained for seven advanced-stage ovarian carcinoma patients and one patient and one patient with primary peritoneal carcinoma. The patient numbers listed correspond with the patient numbers in all subsequent experiments.

ISSN: 1479-5876