Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets

Table 1

Ethnic Group	Class Comparison	Student t test p₂-value < 0.005 # genes differentially expressed	Permutation Test (p-value)
Ethnic Group	Class Comparison		Multivariate	Univariate
a) All Donors (n = 47)	IL-2 vs No-Stim	1690	0	0.007
b) Chinese (n = 17)	IL-2 vs No-Stim	411	0.001	0.019
c) Caucasians (n = 30)	IL-2 vs No-Stim	1340	0	0.009
d) Caucasians (n = 17)	IL-2 vs No-Stim	784	0	0.01
*Ethnic Group*	*Class Comparison*	*Student t test* p ₂ *-value < 0.05* *# genes differentially expressed*	*Permutation Test (p-value)*
			*Multivariate*	*Univariate*
e) All Donors (n = 47)	IL-2 vs No-Stim	3926	0	0

Genes with expression altered by exposure of PBMC in response to rIL-2 (300 IU/ml) in vitro – BMC were obtained from 30 Caucasian (Ca) and 17 Chinese (Ch) normal donors. Class comparison was performed by two-tailed Student t test with as cutoff of significance a p₂-value <0.005 comparing CY5/Cy3 log₂ ratios between test and reference samples (see Materials and Methods). Multivariate and univariate permutation test evaluated the significance of the comparisons.

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