Skip to main content
Figure 5 | Journal of Translational Medicine

Figure 5

From: Combined IL-21 and Low-Dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model

Figure 5

CD27 vs CD62L 2 parameter phenotype analysis of pmel CD8+ T cells. Lymphocytes from pooled blood (5–10 mice/group) in a representative experiment were analyzed for CD127 and CD62L staining. Flow cytometry phenotype analysis of pmel CD8+ T cells on days 14, 21 and 28 post vaccination indicated higher frequencies of antigen specific Tcm (CD62L+/CD127+) were induced at all time points by IL-21 alone compared to the control and IL-2 stimulated PBMCs; IL-21 + IL-2 stimulated comparably high Tcm frequencies on days 21 and 28. IL-21+IL-2 stimulated the highest frequency of pmel CD8+ Tem (CD62L-/CD127+) at all time points.

Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us