Figure 3

Surface antigens identified by the nearest shrunken centroid algorithm and their role as putative prognosticators for B-CLLs. For each antigen identified as part of the immunophenotypic signature, are here reported: i) its expression levels in the three immunophenotypic groups as identified by nearest shrunken centroids (↑ or ↓ indicate above- or below-average expression, respectively; = indicates average expression level) [17]; ii) its association (Y) or lack of association (N) with good or bad prognosis and the relative z scores as resulted by Cox proportional hazard regression analysis [22]; iii) the cutoff values, as resulted by Maximally selected log-rank statistics analysis, and the score values assigned when its expression was found to be above or below the established cutoff [22]. Data and values of the antigens selected for the final prognostic score are reported in red.