Table 3 Human genes belonging to Leukocyte Antigen 6 (Ly-6) gene super family
Gene | Cellular expression | # Cysteine domains | Type of protein | Comments | Location |
|---|---|---|---|---|---|
CD59 | Erythrocytes | 1 | GPI-anchored | Protects cells from membrane attack complex induced lysis | 11p13 |
PSCA | Prostate | 1 | GPI-anchored | Marker of prostate cancer and increase prostate cell division | 8q24.2 |
SLURP-1 (ARS B) | Â | 1 | Secreted | Mutations are associated with Mal de Meleda syndrome | 8q24.3 |
SLURP-2 | Â | 1 | Secreted | Increased expression in skin keratinocytes in psoriasis vulgaris | 8q24.3 |
E-48 (LY6D) | Keratinocytes | 1 | GPI-anchored | Overexpressed in head-and-neck squamous cell carcinoma | 8q24.3 |
RIG-E | Acute promyelocytic leukemia cells | 1 | GPI-anchored | Expression is induced by all-trans-retinoic acid | 8q24.3 |
LY6H | Brain and acute lymphoblastic leukemia | 1 | GPI-anchored | Â | 8q24.3 |
LYGK | Keratinocytes | 1 | GPI-anchored | Overexpressed in head-and-neck squamous cell carcinoma | Â |
GML | Â | 1 | GPI-anchored | Expression is induced by suppressor gene p53 | 8q24.3 |
SP-10 | Sperm and testis | 1 | GPI-anchored | Abnormal RNA splicing is common | 11q23-q24 |
SAMP14 | Spermatozoan | 1 | GPI-anchored | Â | 19q13.33 |
CD177 | Neutrophil | 2 | GPI-anchored | Increased expression in polycythemia vera | 19q13.2 |
uPAR | Neutrophils and monocytes | 3 | GPI-anchored | A high affinity receptor for urokinase type plasminogen activator | 19q13.3 |