Up-regulation of heme oxygenase-1 after infarct initiation reduces mortality, infarct size and left ventricular remodeling: experimental evidence and proof of concept

Table 2 In vivo heart functional parameters of rats by echocardiography at 4 weeks

Heart function	Sham group	MI group	CoPP-MI group	CoPP + SnMP MI group
Heart function	n = 20	n = 35	n = 25	n = 6
LVEDd (mm)	5.5 ± 0.2	7.4 ± 0.4^**#	6.3 ± 0.3^*	8.5 ± 0.4^**#
LVESd (mm)	2.0 ± 0.2	5.0 ± 0.3^**#	2.9 ± 0.1	6.0 ± 0.4^**#
EDAW (mm)	1.6 ± 0.1	1.1 ± 0.1^**#	1.5 ± 0.1	1.1 ± 0.1^**#
EDPW (mm)	1.6 ± 0.1	1.9 ± 0.1^**#	1.6 ± 0.1	1.9 ± 0.7^**#
SAWT%	71 ± 3	35 ± 2^**#	60 ± 3^*	38 ± 5^**#
SPWT%	70 ± 2	41 ± 2^**#	69 ± 2	52 ± 4^**#
FS%	65 ± 3	34 ± 2^**#	54 ± 2^*	29 ± 3^**#
HR	456 ± 7	495 ± 5^**#	443 ± 6	470 ± 9^#

Values are mean ± SEM; n, number of animals tested; LVEDd, left ventricular end-diastole diameter; LVESd, left ventricular end-systole diameter; EDAW, end-diastole anterior wall thickness; EDPW, end-diastole posterior (remote) wall thickness; SAWT%, percent systolic anterior wall thickening; SPWT%, percent systolic posterior (remote) wall thickening; FS%. percent fractional shortening. HR, heart rate. *p < 0.05 and **p < 0.001 vs sham-operated; #p < 0.001 vs CoPP-treated infarct.

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