Figure 6

Functional network for the septic severity biomarker signature. Functional enrichment analyses were performed for the septic severity biomarker signature by using GeneGo MetaCore pathway analysis tool. Map Folders (A) and Pathway Maps (B) outputs are shown. Bars indicate the significance of the results (-log p-value). Only significant results were shown on the right of the bars. (C) A functional network was derived from the septic severity biomarker signature using GeneGo MetaCore. Compared to controls, input genes that are over-expressed and under-expressed in severe sepsis are indicated with red and blue circles, respectively. Red arrows indicate a negative interaction, green arrows indicate a positive interaction, and gray arrows indicate unspecified interactions.