Figure 3From: Potential therapeutic targets for hypoxia-induced pulmonary artery hypertension Effect of 5-HD on the localization of TGF-β1 and MCP-1 protein expression. (A) Positive expression of TGF-β1 was mainly detected in pulmonary arteries and significantly increased in medium and small pulmonary arteries in Hypoxia + V group. (B) Treatment with 5-HD could prevent from hypoxia-induced expression of TGF-β1 in the pulmonary artery. (C) Serum levels of MCP-1 in Hypoxia + V group significantly increased vs Controls, while not in Hypoxia + 5-HD group. Each group includes 8 animals and values were expressed as mean ± SD. *and + stand for p values less than 0.05, as compared with Controls and Hypoxia + V group, respectively.Back to article page