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Table 2 Clinical features

From: In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients

Feature

Genotype 1

Genotype 3

P value*

Patients (n)

18

23

0.7§

Males, n (%)

13 (68)

15 (65)

1§

Females, n (%)

6 (32)

8 (35)

 

Age (years -/+SD)

44.6 -/+13.2

43.2 -/+10.2

0.19

Risk factors, n (%)

   

Injecting drug use

7 (39)

12 (52)

0.53§

Blood transfusion

4 (22)

2 (9)

0.03§

Anti-D immunoglobulin

4 (22)

0 (0)

0.38§

Not determined

3 (17)

9 (39)

0.17§

Liver enzyme levels

   

ALT (IU/L -/+SD)

112.8 -/+122.6

107.4 -/+86.3

0.34

AST (IU/L -/+SD)

66.6 -/+54.8

69.2 -/+59.5

0.5

Leukocyte counts

   

WCC (x 109/L -/+SD)

5.7 -/+2

6.4 -/+2.5

0.3

Neutrophils (x103/μl)

3.3 -/+1.4

3.4 -/+1.7

0.99

Lymphocytes (x103/μl)

1.8 -/+0.6

2.3 -/+1

0.06

Monocytes (x103/μl)

0.46 -/+0.13

0.6 -/+0.3

0.17

Viral load (x106 IU/ml -/+) SD)

5.6 -/+10.8

7.5 -/+1.3

0.31

IL-28B genotype n (%)

   

CC

4 (22)

8 (35)

0.5§

CT/TT

10 (56)

9 (39)

0.36§

Not determined

4 (22)

6 (26)

1§

  1. *Comparison between G1 and G3 infected patients.
  2. §Fisher’s exact test.
  3. Mann–Whitney U test.
  4. ALT alanine aminotrasferase, AST aspartate aminotransferase, WCC white cell count.