Figure 1
Compartmental representation of clozapine and norclozpaine pharmacokinetics. Two compartments in blue represented the plasma and brain compartment of clozapine. Two compartments in green represented the plasma and brain compartment of norclozapine. Clo (Clozapine): CLclo/F (L/min) = apparent clearance of clozapine; Vclo-p/F (L) = apparent volume of distribution of clozapine in plasma; Kaclo (1/min) = absorption rate of clozapine; Qclo/F. (L/min) = apparent intercompartmental clearance of clozapine; Vclo-b /F (L) = apparent volume of distribution of clozapine in brain; Ktr1 (1/min) = transit rate constant of clozapine. Met (Norclozapine): CLclo-met/F (L/min) = apparent clearance of clozapine to norclozapine; CLmet /F (L/min) = apparent clearance of norclozapine; Vmet-p/F (L) = apparent volume of distribution of norclozapine in plasma; Kamet (1/min) = absorption rate of norclozapine; Qmet/F (L/min) = apparent intercompartmental clearance of norclozapine; Vmet-b/F (L) = apparent volume of distribution of norclozapine in brain; Ktr2 (1/min) = transit rate constant of norclozapine.