Figure 3

Combination treatment of PC14PE6-RFP tumor-bearing nude mice with GLV-1h68 and cyclophosphamide. (A) Treatment schedule demonstrating the regimen of GLV-1h68 and CPA treatment in PC14PE6-RFP tumor-bearing mice. (B) Tumor volumes of PC14PE6-RFP tumors treated with or without combination treatment. 4×10⁵ PC14PE6-RFP cells were implanted subcutaneously into the right flank of female nude mice. When tumor volumes reached approximately 100–130 mm³ mice were randomized into four groups (n = 5). Mice were either treated with a single i.v. injection of 1×10⁷ pfu GLV-1h68, with multiple i.p. injections of CPA, a combination of both or with PBS as control. Numbers of surviving mice are indicated in parentheses.