Significantly fewer protein functional changing variants for lipid metabolism in Africans than in Europeans

Table 1 Overview of Genotype datasets used in this study

Dataset	Subpopulation	Group name	Group symbol	Total sample number (n)	Trio-excluded sample number (n)	Total number of SNPs	The number of SNPs with missense mutation	The number of SNPs with harmful (ri>0.2) missense mutation
Hapmap released in May, 2010	European	Utah residents with Northern and Western European ancestry from the CEPH collection	CEU	165	117	1397814	11185	3788
		Toscans in Italy	TSI	102	102	1419970	11160	3778
		Han Chinese in Beijing, China	CHB	137	137	1341772	12205	4441
	Asian	Chinese in Metropolitan Denver, Colorado	CHD	109	109	1311767	9907	3263
	Asian	Japanese in Tokyo, Japan	JPT	113	113	1294406	11008	3887
	African	African ancestry in Southwest USA	ASW	87	75	1543115	12190	4090
		Luhya in Webuye, Kenya	LWK	110	110	1526783	13518	4861
		Maasai in Kinyawa, Kenya	MKK	184	156	1532002	11694	3836
		Yoruba in Ibadan, Nigeria	YRI	203	149	1493761	11583	3880
	Independent groups	Gujarati Indians in Houston, Texas	GIH	101	101	1408904	10491	3471
	Independent groups	Mexican ancestry in Los Angeles, California	MEX	86	58	1453054	12770	4562
1000 Genomes, pilot, low-coverage, released in July, 2010	European	Utah residents with Northern and Western European ancestry from the CEPH collection	CEU	60	60	7724854	86040	14807
	Asian	Han Chinese in Beijing, China and Japanese in Tokyo, Japan	CHB+JPT	60	60	6107825	60584	9912
	African	Yoruba in Ibadan, Nigeria	YRI	59	59	10556156	119798	21055

ISSN: 1479-5876