High intratumoral metastasis-associated in colon cancer-1 expression predicts poor outcomes of cryoablation therapy for advanced hepatocellular carcinoma

Table 3 MACC1 expression and outcomes of post-cryoablation therapy

	MACC1 mRNA expression		P	MACC1 protein localization		P
	High (n = 60)	Low (n = 60)		Cytoplasmic (n = 48)	Nuclear (n = 39)
TTP	4.0	8.5	< 0.001	5.0	4.0	<0.001
TTP	3.0-5.0(M)	6.3-10.7 (M)		4.2-5.8 (M)	3.6-4.4 (M)
OS	9.0	12.0	0.019	11.0	8.0	0.001
OS	7.7-10.3 (M)	7.8-16.2 (M)		8.1-13.9(M)	6.7-9.2(M)
Overall response rate (CR + PR)	5(8.3%)	15(25.0%)	0.027	8(16.7%)	5(12.8%)	0.843
Disease control rate (CR + PR + SD)	31(51.7%)	44(73.3%)	0.027	33(68.8%)	17(43.6%)	0.0321

Abbreviations: Overall response rate: includes complete and partial response. Disease control rate: includes complete, partial response and stable disease. M: months.

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