Table 2 Change in expression of BMSC genes during co-culture with 3 different leukemia cell lines and with CD34 + cells
From: Leukemia cells induce changes in human bone marrow stromal cells
Class comparisona | Up-regulated genes | Down-regulated genes | Most over-represented canonical pathwaysb | ||
|---|---|---|---|---|---|
| Â | Gene symbol | Fold change | Genes symbol | Fold change | Â |
BMSCs co-cultured with TF-1 | CXCL1 | 338.3 | CYP3A4 | -5.9 | Role of IL-17A in arthritis |
| Â | IL8 | 168.8 | PLEKHH2 | -4.2 | Role of IL-17Â F in allergic Inflammatory airway Diseases |
| Â | CXCL3 | 59.4 | CCNF | -4.0 | Role of IL-17A in Psioriasis |
| Â | CXCL2 | 46.6 | CYP3A5 | -3.9 | IL-17A signaling in airway cells |
| Â | PTGS2 | 32.8 | RBM5 | -3.8 | Â |
| Â | IL1B | 26.6 | BMP4 | -3.8 | Â |
| Â | IL1A | 26.5 | ANGPT2 | -3.7 | Â |
| Â | IL1B | 23.1 | GZMB | -3.5 | Â |
| Â | ICAM1 | 21.7 | DAB2IP | -3.5 | Â |
| Â | CCL2 | 19.3 | CYP3A7 | -3.5 | Â |
BMSCs co-cultured with TF-1α | IRF8 | 4.2 | Col3a1 | -14.4 | Rac signaling |
| Â | SLC30A4 | 4.0 | Gria1 | -6.6 | D-myo-inositol(1,4,5) triphosphate biosynthesis |
| Â | CDH7 | 3.2 | ASB5 | -5.5 | |
| Â | DZANK1 | 3.0 | ABCC9 | -5.2 | Actin cytoskeleton signaling |
| Â | GDF2 | 3.0 | DBIL5P | -4.2 | Growth hormone signaling |
| Â | NPTX1 | 2.9 | CALB2 | -3.5 | Death receptor signaling |
| Â | ATPBD4 | 2.9 | TMEM242 | -3.5 | Â |
| Â | UNC5C | 2.9 | EIF4EBP2 | -3.4 | Â |
| Â | YOD1 | 2.9 | -3.1 | Â | |
| Â | CCL28 | 2.8 | MLL2 | -3.0 | Â |
BMSCs co-cultured with K562 | IL8 | 17.4 | SPOCK3 | -7.1 | Role of IL-17A in arthritis |
| Â | CCL2 | 12.6 | KANK4 | -6.5 | Hepatic fibrosis/stellate cell activation |
| Â | PTPRR | 11.9 | PRSS35 | -6.5 | VDR/RXR activation |
| Â | IL1B | 11.6 | GPR85 | -5.5 | CD40 signaling |
| Â | CXCL1 | 9.2 | FGF7 | -4.7 | IL-6 signaling |
| Â | ICAM1 | 8.4 | SLC8A1 | -4.6 | Â |
| Â | SLC25A21 | 7.6 | AP4E1 | -4.6 | Â |
| Â | SERPINB2 | 7.5 | ABCC9 | -4.2 | Â |
| Â | SLC44A4 | 6.1 | C17orf28 | -4.2 | Â |
| Â | FAM167A | 5.0 | FLT1 | -4.1 | Â |
BMSCs co-cultured with CD34 + cells | SERPINB2 | 3.5 | UGT2B10 | -2.9 | Purine metabolism |
| Â | IL1B | 3.4 | METTL3 | -2.7 | Estrogen receptor signaling |
| Â | RTP3 | 2.8 | SFP2 | -2.6 | mTOR signaling |
| Â | ZBED2 | 2.7 | C5AR1 | -2.5 | EIF2 signaling |
| Â | CCL7 | 2.6 | ISL2 | -2.5 | Aminosugars metabolism |
| Â | ERMN | 2.6 | KLRC3 | -2.4 | Â |
| Â | IL8 | 2.6 | EFHD1 | -2.3 | Â |
| Â | NKAPL | 2.5 | RFX4 | -2.3 | Â |
| Â | TSLP | 2.4 | KANK4 | -2.2 | Â |