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Table 1 86 differentially expressed miRNA (pā€‰<ā€‰0.05) R: regulation of miRNA (ā†‘ up-regulated; ā†“ down-regulated and -no difference)

From: Circulating microRNA: a novel potential biomarker for early diagnosis of Intracranial Aneurysm Rupture a case control study

Ā 

miRNA

A/control

B/control

C/control

Ā Ā 

R

P

FC

R

P

FC

R

P

FC

1

hsa-miR-584

ā†‘

0.000

2.2

Ā Ā Ā Ā Ā Ā 

2

hsa-miR-301a

ā†‘

0.001

2.2

-

Ā Ā 

-

Ā Ā 

3

hsa-miR-3679-5p

ā†‘

0.002

18.8

-

Ā Ā 

-

Ā Ā 

4

hsa-miR-575

ā†‘

0.003

18.9

-

Ā Ā 

-

Ā Ā 

5

hsa-miR-671-5p

ā†‘

0.003

16.1

-

Ā Ā 

-

Ā Ā 

6

hsa-miR-22

ā†‘

0.003

11.8

-

Ā Ā 

-

Ā Ā 

7

hsa-miR-720

ā†‘

0.003

23.4

-

Ā Ā 

-

Ā Ā 

8

hsa-miR-1915

ā†‘

0.004

11.1

-

Ā Ā 

-

Ā Ā 

9

hsa-miR-3665

ā†‘

0.004

11.6

-

Ā Ā 

-

Ā Ā 

10

hsa-miR-939

ā†‘

0.004

14.7

-

Ā Ā 

-

Ā Ā 

11

hsa-miR-3915

ā†‘

0.005

14.4

-

Ā Ā 

-

Ā Ā 

12

hsa-miR-630

ā†‘

0.005

14.8

-

Ā Ā 

-

Ā Ā 

13

hsa-miR-320d

ā†‘

0.005

14.4

-

Ā Ā 

-

Ā Ā 

14

hsv2-miR-H10

ā†‘

0.005

11.3

-

Ā Ā 

-

Ā Ā 

15

hsa-miR-3656

ā†‘

0.005

11.8

-

Ā Ā 

-

Ā Ā 

16

hsa-miR-320e

ā†‘

0.005

14.3

-

Ā Ā 

-

Ā Ā 

17

hsa-miR-1207-5p

ā†‘

0.005

12.8

-

Ā Ā 

-

Ā Ā 

18

hsa-miR-125b-1*

ā†‘

0.005

44.9

-

Ā Ā 

-

Ā Ā 

19

hsa-miR-486-5p

ā†‘

0.005

16.8

Ā Ā Ā 

-

Ā Ā 

20

hsa-miR-498

ā†‘

0.005

14.7

Ā Ā Ā 

-

Ā Ā 

21

kshv-miR-K12-3

ā†‘

0.006

10.6

-

Ā Ā 

-

Ā Ā 

22

hsa-miR-4270

ā†‘

0.006

12.0

-

Ā Ā 

-

Ā Ā 

23

hsa-miR-30d

ā†‘

0.007

14.4

-

Ā Ā 

-

Ā Ā 

24

hsa-miR-24

ā†‘

0.006

7.93

-

Ā Ā 

-

Ā Ā 

25

hsa-miR-1202

ā†‘

0.007

12.1

-

Ā Ā 

-

Ā Ā 

26

hsa-miR-4281

ā†‘

0.007

10.9

-

Ā Ā 

-

Ā Ā 

27

hsa-miR-638

ā†‘

0.007

10.2

-

Ā Ā 

-

Ā Ā 

28

hsa-miR-2861

ā†‘

0.007

10.0

-

Ā Ā 

-

Ā Ā 

29

hsa-miR-494

ā†‘

0.007

24.8

-

Ā Ā 

-

Ā Ā 

30

hsa-miR-134

ā†‘

0.007

11.2

-

Ā Ā 

-

Ā Ā 

31

hsa-miR-3162

ā†‘

0.007

13.3

-

Ā Ā 

-

Ā Ā 

32

hsa-miR-4298

ā†‘

0.007

13.0

-

Ā Ā 

-

Ā Ā 

33

hsa-miR-3663-3p

ā†‘

0.008

11.3

-

Ā Ā 

-

Ā Ā 

34

hsa-miR-92a

ā†‘

0.008

12.4

-

Ā Ā 

-

Ā Ā 

35

hsa-miR-4271

ā†‘

0.008

13.2

-

Ā Ā 

-

Ā Ā 

36

hsa-miR-106b

ā†‘

0.008

10.6

Ā Ā Ā 

-

Ā Ā 

37

hsa-miR-21

ā†‘

0.009

7.4

-

Ā Ā 

ā†‘

Ā Ā 

38

hsa-miR-3141

ā†‘

0.009

11.5

-

Ā Ā 

-

Ā Ā 

39

hsa-miR-125a-3p

ā†‘

0.009

14.0

-

Ā Ā 

-

Ā Ā 

40

hsa-miR-4306

ā†‘

0.010

9.2

-

Ā Ā 

-

Ā Ā 

41

hsa-miR-1225-5p

ā†‘

0.010

10.2

-

Ā Ā 

-

Ā Ā 

42

hsa-miR-423-5p

ā†‘

0.010

11.9

-

Ā Ā 

-

Ā Ā 

43

hsa-miR-197

ā†‘

0.011

7.52

-

Ā Ā 

-

Ā Ā 

44

hsa-miR-1268

ā†‘

0.011

9.9

-

Ā Ā 

-

Ā Ā 

45

hsv2-miR-H25

ā†‘

0.012

7.7

-

Ā Ā 

-

Ā Ā 

46

hsv2-miR-H24

ā†‘

0.013

11.9

-

Ā Ā 

-

Ā Ā 

47

hsa-miR-25

ā†‘

0.013

6.8

-

Ā Ā 

-

Ā Ā 

48

hsa-miR-93

ā†‘

0.014

8.1

-

Ā Ā 

-

Ā Ā 

49

hsa-miR-765

ā†‘

0.014

13.5

-

Ā Ā 

-

Ā Ā 

50

hsv2-miR-H6

ā†‘

0.015

9.0

-

Ā Ā 

-

Ā Ā 

51

hsa-miR-940

ā†‘

0.016

14.0

-

Ā Ā 

-

Ā Ā 

52

hsa-let-7d*

ā†‘

0.016

8.4

-

Ā Ā 

-

Ā Ā 

53

hsa-miR-19b

ā†‘

0.017

5.1

-

Ā Ā 

-

Ā Ā 

54

hsa-miR-483-5p

ā†‘

0.018

10.1

-

Ā Ā 

-

Ā Ā 

55

hsa-let-7i

ā†‘

0.017

8.3

Ā Ā Ā 

-

Ā Ā 

56

hsa-miR-4327

ā†‘

0.019

11.2

-

Ā Ā 

-

Ā Ā 

57

hsv1-miR-H17

ā†‘

0.019

6.8

-

Ā Ā 

-

Ā Ā 

58

hsa-miR-1275

ā†‘

0.021

9.5

-

Ā Ā 

-

Ā Ā 

59

hsa-let-7b

ā†‘

0.022

10.0

-

Ā Ā 

-

Ā Ā 

60

hsa-miR-15b

ā†‘

0.023

5.3

-

Ā Ā 

-

Ā Ā 

61

hsa-miR-320c

ā†‘

0.023

8.3

-

Ā Ā 

-

Ā Ā 

62

hsa-miR-144

ā†‘

0.025

8.0

-

Ā Ā 

-

Ā Ā 

63

hsa-miR-762

ā†‘

0.027

7.4

-

Ā Ā 

-

Ā Ā 

64

hsa-miR-223

ā†‘

0.030

4.4

-

Ā Ā 

-

Ā Ā 

65

hsa-miR-3663-5p

ā†‘

0.042

9.3

-

Ā Ā 

-

Ā Ā 

66

hsa-miR-151-3p

ā†‘

0.043

7.0

-

Ā Ā 

-

Ā Ā 

67

hsa-miR-601

ā†‘

0.045

7.2

-

Ā Ā 

-

Ā Ā 

68

hsv1-miR-H6-5p

ā†‘

0.045

5.8

-

Ā Ā 

-

Ā Ā 

69

hsa-miR-1471

-

Ā Ā 

ā†“

0.000

25.9

-

Ā Ā 

70

hsa-miR-3945

-

Ā Ā 

ā†“

0.002

14.2

-

Ā Ā 

71

hsa-miR-574-5p

-

Ā Ā 

ā†“

0.004

16.5

Ā Ā Ā 

72

hsa-miR-4314

-

Ā Ā 

ā†“

0.004

14.5

-

Ā Ā 

73

hsa-miR-1914*

-

Ā Ā 

ā†“

0.008

13.0

-

Ā Ā 

74

hsa-miR-30c-2*

-

Ā Ā 

ā†“

0.010

8.3

Ā Ā Ā 

75

hsa-miR-22

-

Ā Ā 

ā†‘

0.022

3.1

Ā Ā Ā 

76

hsa-miR-720

-

Ā Ā 

ā†‘

0.027

4.3

Ā Ā Ā 

77

hsa-miR-1182

-

Ā Ā 

ā†“

0.028

6.3

Ā Ā Ā 

78

hsa-miR-4253

-

Ā Ā 

ā†“

0.029

6.7

Ā Ā Ā 

79

hsa-miR-3665

-

Ā Ā 

ā†‘

0.034

2.6

Ā Ā Ā 

80

hsa-miR-1226*

-

Ā Ā 

ā†“

0.034

6.7

Ā Ā Ā 

81

hsa-miR-21

-

Ā Ā 

ā†‘

0.039

2.1

Ā Ā Ā 

82

hsa-miR-3945

-

Ā Ā 

-

Ā Ā 

ā†“

0.002

14.7

83

hsa-miR-4314

-

Ā Ā 

-

Ā Ā 

ā†“

0.003

14.9

84

hsa-miR-365

-

Ā Ā 

-

Ā Ā 

ā†“

0.003

12.6

85

ebv-miR-BART13

-

Ā Ā 

-

Ā Ā 

ā†“

0.004

12.8

86

hsa-miR-4253

-

Ā Ā 

-

Ā Ā 

ā†“

0.005

11.6

87

hsa-miR-936

-

Ā Ā 

-

Ā Ā 

ā†“

0.008

12.5

88

hsa-miR-574-5p

-

Ā Ā 

-

Ā Ā 

ā†“

0.014

9.9

89

hsa-miR-1471

-

Ā Ā 

-

Ā Ā 

ā†“

0.019

9.0

90

hsa-miR-187*

-

Ā Ā 

-

Ā Ā 

ā†“

0.032

7.5

91

hsa-miR-548q

-

Ā Ā 

-

Ā Ā 

ā†“

0.038

7.0

92

hsa-miR-3194

-

Ā Ā 

-

Ā Ā 

ā†“

0.040

7.9

93

hsa-miR-371-5p

-

Ā Ā 

-

Ā Ā 

ā†“

0.045

5.8

94

kshv-miR-K12-7*

-

Ā Ā 

-

Ā Ā 

ā†“

0.046

8.7

95

hsa-miR-199a-5p

-

Ā Ā 

-

Ā Ā 

ā†‘

0.046

3.8

96

hsa-miR-3679-5p

-

Ā Ā 

-

Ā Ā 

ā†‘

0.048

3.3

  1. P: Significant P value, the smaller P is, the bigger the difference will be. FC: Absolute value of difference between groups. As is revealed, 86 out of all the miRNAs probes have significantly different expression level. Compared with control group, 68 miRNA are up-regulated and none is down-regulated in team A, 4 are up-regulated and 9 down-regulated in team B, 2 are up-regulated and 13 are down-regulated in team C.
  2. *means low expression. It is a symbol based on naming rule of miRNA.
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Journal of Translational Medicine

ISSN: 1479-5876

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